He has appeared in many plays and films, and was nominated for BAFTA awards for his roles in A Room with a View (1985) and Four Weddings and a Funeral (1994).
He has written several books, including Being an Actor and biographies of Oscar Wilde, Charles Laughton and Orson Welles. Love is where it falls is the story of his passionate but platonic relationship with the theatrical agent Peggy Ramsay, against thee background of his own gay relationships.
- "I'm not really an activist, although I am aware that there are some political acts one can do that actually make a difference and I think my coming out as a gay man was probably one of the most valuable things I've done in my life. I don't think any actor had done so voluntarily and I think it helped to change the culture."
- http://www.independent.co.uk/arts-entertainment/theatre-dance/features/simon-callow-laughter-in-the-dark-561274.html Sholto Byrnes, "Simon Callow: Laughter in the dark, interview" The Independent, 26 April 2004
- https://archive.is/nYVfA#selection-827.0-827.175 .Actor Simon Callow attacks Stonewall, the LGBTQ+ group, over trans self-identification The Times Scotland 25 August 2021